The Apple Original Film, which also stars Robert DeNiro (as William Hale), Leonardo DiCaprio (as Ernest Burkhart) and Jesse Plemons (as Tom White) is based on the 2017 nonfiction book Killers of the Flower Moon: The Osage Murders and the Birth of the F.B.I. by David Grann.
According to Variety, the movie "takes place in 1920s Oklahoma and depicts a string of brutal murders of Osage Nation Native Americans, which came to be known as the Reign of Terror."
Isbell will portray Bill Smith, the white husband of an Osage woman who is killed, while Simpson will portray Henry Grammer, a bootlegger and rodeo champion.
Indigenous actor William Belleau will portray Henry Roan and Louis Cancelmi will portray Kelcie Morrison.
Lily Gladstone, Tantoo Cardinal, Cara Jade Myers, JaNae Collins and Jillian Dion will also star.
When I say I am EXCITED https://t.co/7fl0A6npZx
— Jason Isbell (@JasonIsbell) April 6, 2021
Simpson is no stranger to film roles. The "Turtles All the Way Down" singer appeared in The Dead Don't Die, Queen & Slim and The Hunt.
Isbell appeared as an extra in Deadwood: The Movie and voiced Pastor Nubbins in the animated series Squidbillies.
Simpson released his most recent album, Cuttin' Grass: Vol. 2, in 2020.
Isbell released Reunions with his band, the 400 Unit, last year.